The P-glycoprotein content in glandular epithelial cells was significantly lower on day 0 and day 15 as compared to day 15 in the rats treated with estradiol-17 beta.(ABSTRACT TRUNCATED AT 250 WORDS)1. On the other hand, in the rats treated with the vehicle, there was no significant difference in the P-glycoprotein content in luminal epithelial cells obtained on day 0 and day 15. After day 0, the P-glycoprotein content in luminal epithelial cells was significantly lower on day 15 than on day 0. The P-glycoprotein content in uterine luminal epithelial cells was significantly lower on day 0 as compared to day 15 in the rats treated with or without estradiol-17 beta. The expression of the P-glycoprotein in each tissue was determined by Western blot analysis with a monoclonal antibody. Whole uterine tissue, luminal epithelium and glandular epithelium were obtained by scraping. Rats were treated with estradiol-17 beta at 0.1 mg/kg body weight for 15 consecutive days or with the vehicle of estradiol-17 beta for the same period. Ovariectomized rats were treated with or without estradiol-17 beta. This study was undertaken to determine whether the P-glycoprotein is altered by the endogenous or exogenous estrogen in uterine endometrium of the rat. It is suggested that resistance to various drugs by the cells of some organs and tissues occurs because of active efflux mediated by a membrane transporter protein, P-glycoprotein. Total war online.Endogenous and exogenous estrogen alters the distribution of the P-glycoprotein in uterine luminal and glandular epithelial cells of the rat. If you are looking for a free game Rome: Total War Online is a great. Rome: Total War Online (2003) from NEO, Free Download.
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